Cytokinesis in trypanosomatids

Hammarton, T. C. , Monnerat, S. and Mottram, J. C. (2007) Cytokinesis in trypanosomatids. Current Opinion in Microbiology, 10(6), pp. 520-527. (doi:10.1016/j.mib.2007.10.005)

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Publisher's URL: http://dx.doi.org/10.1016/j.mib.2007.10.005

Abstract

The process of cytokinesis, where the cytoplasm of one cell is divided to produce two daughter cells, is intricate in trypanosomatids because of the requirement to replicate and segregate a number of single copy organelles, including the nucleus, kinetoplast, Golgi apparatus, and flagellum. Identifying regulators of the three stages of cytokinesis, initiation, furrow ingression, and abscission is complicated by the fact that cell division in trypanosomatids is easily perturbed and aberrant cells are readily produced during functional characterization of gene products. In this review, we discuss direct and indirect effects on cytokinesis, using Trypanosoma brucei as a model.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hammarton, Dr Tansy and Monnerat, Dr Severine and Mottram, Professor Jeremy
Authors: Hammarton, T. C., Monnerat, S., and Mottram, J. C.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Current Opinion in Microbiology
Publisher:Elsevier
ISSN:1369-5274
ISSN (Online):1879-0364
Published Online:26 November 2007
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
403591Regulation of cytokinesis in trypanosoma bruceiTansy HammartonMedical Research Council (MRC)G120/1001Infection Immunity and Inflammation Life Sciences