CoreValve vs. Sapien 3 transcatheter aortic valve replacement: a finite element analysis study

Nappi, F., Mazzocchi, L., Spadaccio, C., Attias, D., Timofeva, I., Macron, L., Iervolino, A., Morganti, S. and Auricchio, F. (2021) CoreValve vs. Sapien 3 transcatheter aortic valve replacement: a finite element analysis study. Bioengineering, 8(5), 52. (doi: 10.3390/bioengineering8050052) (PMID:33925437) (PMCID:PMC8146716)

Abstract

Aim: to investigate the factors implied in the development of postoperative complications in both self-expandable and balloon-expandable transcatheter heart valves by means of finite element analysis (FEA). Materials and methods: FEA was integrated into CT scans to investigate two cases of postoperative device failure for valve thrombosis after the successful implantation of a CoreValve and a Sapien 3 valve. Data were then compared with two patients who had undergone uncomplicated transcatheter heart valve replacement (TAVR) with the same types of valves. Results: Computational biomechanical modeling showed calcifications persisting after device expansion, not visible on the CT scan. These calcifications determined geometrical distortion and elliptical deformation of the valve predisposing to hemodynamic disturbances and potential thrombosis. Increased regional stress was also identified in correspondence to the areas of distortion with the associated paravalvular leak. Conclusion: the use of FEA as an adjunct to preoperative imaging might assist patient selection and procedure planning as well as help in the detection and prevention of TAVR complications.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Spadaccio, Dr Cristiano

Creator Roles

Spadaccio, C.: Methodology, Validation, Writing – review and editing

• Authors: Nappi, F., Mazzocchi, L., Spadaccio, C., Attias, D., Timofeva, I., Macron, L., Iervolino, A., Morganti, S., and Auricchio, F.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Bioengineering
• Publisher: MDPI
• ISSN: 2306-5354
• ISSN (Online): 2306-5354
• Published Online: 27 April 2021
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in Bioengineering 8(5): 52
• Publisher Policy: Reproduced under a Creative Commons License