Sphingolipids in HDL – potential markers for adaptation to pregnancy?

Patanapirunhakit, P., Karlsson, H., Mulder, M., Ljunggren, S., Graham, D. and Freeman, D. (2021) Sphingolipids in HDL – potential markers for adaptation to pregnancy? Biochimica et Biophysica Acta: Molecular and Cell Biology of Lipids, 1866(8), 158955. (doi: 10.1016/j.bbalip.2021.158955) (PMID:33933650)

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Abstract

Plasma high density lipoprotein (HDL) exhibits many functions that render it an effective endothelial protective agent and may underlie its potential role in protecting the maternal vascular endothelium during pregnancy. In non-pregnant individuals, the HDL lipidome is altered in metabolic disease compared to healthy individuals and is linked to reduced cholesterol efflux, an effect that can be reversed by lifestyle management. Specific sphingolipids such as sphingosine-1-phosphate (S1P) have been shown to mediate the vaso-dilatory effects of plasma HDL via interaction with the endothelial nitric oxide synthase pathway. This review describes the relationship between plasma HDL and vascular function during healthy pregnancy and details how this is lost in pre-eclampsia, a disorder of pregnancy associated with widespread endothelial dysfunction. Evidence of a role for HDL sphingolipids, in particular S1P and ceramide, in cardiovascular disease and in healthy pregnancy and pre-eclampsia is discussed. Available data suggest that HDL-S1P and HDL-ceramide can mediate vascular protection in healthy pregnancy but not in preeclampsia. HDL sphingolipids thus are of potential importance in the healthy maternal adaptation to pregnancy.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Graham, Dr Delyth and Freeman, Dr Dilys and Patanapirunhakit, Patamat
Authors: Patanapirunhakit, P., Karlsson, H., Mulder, M., Ljunggren, S., Graham, D., and Freeman, D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Biochimica et Biophysica Acta: Molecular and Cell Biology of Lipids
Publisher:Elsevier
ISSN:1388-1981
ISSN (Online):1879-2618
Published Online:29 April 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Biochimica et Biophysica Acta: Molecular and Cell Biology of Lipids 1866(8): 158955
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
190814BHF centre of excellenceRhian TouyzBritish Heart Foundation (BHF)RE/13/5/30177Institute of Cardiovascular & Medical Sciences
302659Vaso-protective properties of maternal high density lipoprotein (HDL) in metabolic complications of pregnancyDilys FreemanNHS Greater Glasgow and Clyde Endowment Funds (NHSGGCEN)GN17OG441- G47372CAMS - Cardiovascular Science