Label-free glucose detection over a wide dynamic range by mesoporous Si nanowires based on anomalous photoluminescence enhancement

Ghosh, R. , Das, R. and Giri, P.K. (2018) Label-free glucose detection over a wide dynamic range by mesoporous Si nanowires based on anomalous photoluminescence enhancement. Sensors and Actuators B: Chemical, 260, pp. 693-704. (doi: 10.1016/j.snb.2018.01.099)

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Abstract

We report on the label-free glucose detection over a wide dynamic range by mesoporous Si nanowires (NWs) through its photoluminescence (PL) quenching and anomalous PL enhancement caused by glucose (GL) in presence of its conjugate enzyme glucose oxidase (GOx). The GL and GOx induced surface evolution of Si NWs is examined by several spectroscopic tools. At a low concentration of GL, the visible-NIR PL emission from Si NWs is partially quenched due to the electron removal by the H2O2 produced by the GL/GOx solution. At higher concentration of GL, the Sisingle bondH bonds on the surface of the Si NWs are eliminated and different functional groups, e.g., Csingle bondC, Cdouble bondC, Csingle bondOH, Cdouble bondO and COOH are attached. This makes the Si NWs highly photoluminescent as compared to the bare Si NWs. The linear response of the PL enhancement of Si NWs with the logarithm of GL concentration is utilized for the label free sensitive detection of GL. A high dynamic range (0.1–50 mM) for GL detection and a considerable lower limit of detection (1.06 μM) are achieved for the newly developed biosensor. This report opens up possibilities for exploiting the low cost mesoporous Si NW arrays for ultrasensitive biosensing and bioimaging applications.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ghosh, Dr Ramesh
Authors: Ghosh, R., Das, R., and Giri, P.K.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Sensors and Actuators B: Chemical
Publisher:Elsevier
ISSN:0925-4005
ISSN (Online):1873-3077
Published Online:09 January 2018

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