Singh, M. and Jaiswal, N. P. (2014) Intermittent versus daily treatment for childhood tuberculosis: current evidence. Clinical Epidemiology and Global Health, 2(2), pp. 95-96. (doi: 10.1016/j.cegh.2014.05.002)
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Abstract
Lack of uniform guidelines for treatment of childhood tuberculosis in high burden countries from Asia and Africa is a major concern. The present Cochrane review has tried to bridge the gap and has found that treatment in terms of radiological evidence and symptoms with twice-weekly regime and daily regime is comparable but the evidence is scares and low-grade and has thus rightly called for adequately powered, multi-centric, multi-country, randomized, non-inferiority, pragmatic trials conducted in high TB-transmission settings, in low- and middle-income countries that compare thrice-weekly, and daily short-course (6 months) dosing, and using the currently recommended four drugs, in HIV-negative children to help inform policy. There is further need for comparing the thrice-weekly regime with the daily and twice-weekly regimes and also a dose wise analysis of the drugs is required. Until this we must follow the WHO guidelines.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Jaiswal, Dr Nishant |
| Authors: | Singh, M., and Jaiswal, N. P. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Health Economics and Health Technology Assessment |
| Journal Name: | Clinical Epidemiology and Global Health |
| Publisher: | Elsevier |
| ISSN: | 2452-0918 |
| ISSN (Online): | 2213-3984 |
| Published Online: | 10 June 2014 |
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