Autoimmune polyendocrine syndrome in a standard poodle with concurrent non-endocrine immune-mediated diseases

Kuijlaars, M., Yool, D. A. and Ridyard, A. E. (2021) Autoimmune polyendocrine syndrome in a standard poodle with concurrent non-endocrine immune-mediated diseases. Veterinary Record Case Reports, 9(3), e90. (doi: 10.1002/vrc2.90)

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Abstract

A 6-year-old female neutered standard poodle was referred with a 4-week history of rapidly progressive weight loss, muscle atrophy, hyporexia, hind limb weakness and lethargy. In the preceding 3-month period, the dog had been diagnosed with both keratoconjunctivitis sicca (KCS) and hypoadrenocorticism. Clinical deterioration had occurred despite treatment for hypoadrenocorticism. Following referral, the dog was diagnosed with concurrent hypothyroidism, exocrine pancreatic insufficiency (EPI) and suspected generalised myositis. Treatment with hormone replacement therapy, pancreatic enzyme supplementation and immunosuppressive doses of prednisolone and mycophenolate resulted in marked clinical improvement. This case describes a rapidly progressive, presumed autoimmune, polyglandular endocrinopathy in a dog with concurrent non-endocrine autoimmune diseases.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Yool, Professor Donald and Ridyard, Ms Alison and Kuijlaars, Margaux
Authors: Kuijlaars, M., Yool, D. A., and Ridyard, A. E.
College/School:College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Veterinary Record Case Reports
Publisher:Wiley
ISSN:2052-6121
ISSN (Online):2052-6121
Published Online:26 May 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Veterinary Record Case Reports 9(3): e90
Publisher Policy:Reproduced under a Creative Commons licence

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