Urea-urease reaction in controlling properties of supramolecular hydrogels: pros and cons

Panja, S. and Adams, D. J. (2021) Urea-urease reaction in controlling properties of supramolecular hydrogels: pros and cons. Chemistry: A European Journal, 27(35), pp. 8928-8939. (doi: 10.1002/chem.202100490) (PMID:33861488)

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Supramolecular hydrogels are useful in many areas such as cell culturing, catalysis, sensing, tissue engineering, drug delivery, environmental remediation and optoelectronics. The gels need specific properties for each application. The properties arise from a fibrous network that forms the matrix. A common method to prepare hydrogels is to use a pH change. Most methods result in a sudden pH jump and often lead to gels that are hard to reproduce and control. The urease‐urea reaction can be used to control hydrogel properties by a uniform and controlled pH increase as well as to set up pH cycles. The reaction involves hydrolysis of urea by urease and production of ammonia which increases the pH. The rate of ammonia production can be controlled which can be used to prepare gels with differing properties. Here we show how the urease‐urea reaction can be used for the construction of next generation functional materials.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Adams, Dave and Panja, Dr Santanu
Authors: Panja, S., and Adams, D. J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Chemistry: A European Journal
ISSN (Online):1521-3765
Published Online:16 April 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Chemistry: A European Journal 27(35): 8928-8939
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
303747Digital-Chemical-Robotics for Translation of Code to Molecules and Complex Chemical SystemsLeroy CroninEngineering and Physical Sciences Research Council (EPSRC)EP/S019472/1Chemistry