Photo scattering signal amplification in gold-viral particle ligation towards fast infection screening

Zhang, H. et al. (2021) Photo scattering signal amplification in gold-viral particle ligation towards fast infection screening. IEEE Photonics Journal, 13(3), 3900111. (doi: 10.1109/JPHOT.2021.3074386)

Abstract

The polarization states of scattered photons can be used to map or image the anisotropic features of a nanostructure. However, the scattering strength depends heavily on the refractivity contrast in the near field under measurement, which limits the imaging sensitivity for viral particles which have little refractivity contrast with their nano-ambientes. In this paper, we show the photon scattering signal strength can be magnified by introducing a more abrupt change of refractivity at the virus particle using antibody-conjugated gold nanoparticles (AuNPs), allowing the presence of such viruses to be detected. Using two different deep learning methods to minimize scattering noise, the photon states scattering signal of a AuNPs ligated virus is enhanced significantly compared to that of a bare virus particle. This is confirmed by Finite Difference Time Domain (FDTD) numerical simulations. The sensitivity of the polarization state scattering spectra from a virus-gold particle doublet is 5.4 times higher than that of a conventional microscope image.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Liu, Professor Xuefeng and Marsh, Professor John and Hou, Dr Lianping
• Authors: Zhang, H., Jin, X., Zhao, H., Lin, Y., Li, X., Hou, L., Marsh, J. H., Dong, L., Shi, D., Liu, W., Xu, B., Ni, B., Liu, J., Xiong, J., and Liu, X.
• College/School: College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
• Journal Name: IEEE Photonics Journal
• Publisher: IEEE
• ISSN: 1943-0655
• ISSN (Online): 1943-0655
• Published Online: 20 April 2021
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in IEEE Photonics Journal 13(3): 3900111
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
302617		Optically controlled THz phased array antennas	John Marsh	Engineering and Physical Sciences Research Council (EPSRC)	EP/R042578/1	ENG - Electronics & Nanoscale Engineering