Application of proteomic biomarkers in livestock disease management

Oskoueian, E., Eckersall, P. D. , Bencurova, E. and Dandekar, T. (2016) Application of proteomic biomarkers in livestock disease management. In: Salekdeh, G. H. (ed.) Agricultural Proteomics Volume 2. Springer, pp. 299-310. ISBN 9783319432786 (doi:10.1007/978-3-319-43278-6_14)

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The applications of proteomics in animal husbanding are broad and include monitoring proteome changes in the tissue and body fluids to interpret the physiological process during growth, development and production and in the detection and management of disease. The diversity of farm animal species from cattle, sheep, goats, chickens to fish and even invertebrate aquaculture species complicate the analysis and interpretation of proteome data. The recent technological advances in extraction and fractionation techniques along with platform sensitivity and data analysis have allowed discovery of next-generation biomarkers with high sensitivity, specificity and precision. These robust biomarkers are useful in monitoring health and well-being of animals, surveillance against animal pathogens, elucidating disease mechanisms, assessing pharmacologic response to therapeutic and directing genetic selection and breeding. A literature survey revealed that discovery of proteomic biomarkers in biological fluids (serum, plasma, urine, milk, exudates, tear, semen and genital secretion) provide readily accessible sources of samples for non- or minimally-invasive and cost-effective diagnosis tools. This area of research is actively expanding and future research would profitably focus on applications of multiple biomarkers to increase the diagnosis precision in livestock disease management. Therefore this review is aimed to provide a brief overview on successful experiences in using proteomics biomarkers identified in biological fluids for livestock diseases management.

Item Type:Book Sections
Additional Information:Print ISBN: 9783319432762.
Glasgow Author(s) Enlighten ID:Eckersall, Professor David
Authors: Oskoueian, E., Eckersall, P. D., Bencurova, E., and Dandekar, T.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
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