Using fast visual rhythmic stimulation to control inter-hemispheric phase offsets in visual areas

Chen, Q., Wang, D., Shapiro, K. and Hanslmayr, S. (2021) Using fast visual rhythmic stimulation to control inter-hemispheric phase offsets in visual areas. Neuropsychologia, 157, 107863. (doi: 10.1016/j.neuropsychologia.2021.107863) (PMID:33872643)

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Abstract

Spike timing dependent plasticity (STDP) is believed to be important for neural communication and plasticity in human episodic memory, but causal evidence is lacking due to technical challenges. Rhythmic sensory stimulation that has been used to investigate causal relations between oscillations and cognition may be able to address this question. The challenge, however, is that the frequency corresponding to the critical time window for STDP is gamma (∼40 Hz), yet the application of rhythmic sensory stimulation has been limited primarily to lower frequencies (<30 Hz). It remains unknown whether this method can be applied to precisely control the activation time delay between distant groups of neurons at a millisecond scale. To answer this question and examine the role of STDP in human episodic memory, we simulated the STDP function by controlling the activation time delay between the left and right visual cortices during memory encoding. This was achieved by presenting flickering (37.5 Hz) movie pairs in the left and right visual fields with a phase lag of either 0, 90, 180 or 270 degrees. Participants were asked to memorize the two movies within each pair and the association was later tested. Behavioral results revealed no significant difference in memory performance across conditions with different degrees of gamma phase synchrony. Yet importantly, our study showed for the first time, that oscillatory activity can be driven with a precision of 6.67 ms delay between neuronal groups. Our method hereby provides an approach to investigate relations between precise neuronal timing and cognitive functions.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hanslmayr, Professor Simon and Wang, Dr Danying
Creator Roles:
Wang, D.Project administration, Methodology, Investigation, Writing – review and editing
Hanslmayr, S.Conceptualization, Supervision, Writing – review and editing, Software, Methodology, Project administration, Funding acquisition
Authors: Chen, Q., Wang, D., Shapiro, K., and Hanslmayr, S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Neuropsychologia
Publisher:Elsevier
ISSN:0028-3932
ISSN (Online):1873-3514
Published Online:16 April 2021
Copyright Holders:Copyright © 2021 Elsevier Ltd.
First Published:First published in Neuropsychologia 157: 107863
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
313261Neural oscillations - a code for memorySimon HanslmayrEuropean Commission (EC)N/ANP - Centre for Cognitive Neuroimaging (CCNi)
314597TIME - GLUING CROSS-MODAL MEMORIES VIA SYNCHRONISATIONSimon HanslmayrEconomic and Social Research Council (ESRC)ES/R010072/2NP - Centre for Cognitive Neuroimaging (CCNi)