Lane, D. and Vousden, K. (2007) p53 in health and disease. Nature Reviews Molecular Cell Biology, 8(4), pp. 275-283. (doi: 10.1038/nrm2147)
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Abstract
As a component of the response to acute stress, p53 has a well established role in protecting against cancer development. However, it is now becoming clear that p53 can have a much broader role and can contribute to the development, life expectancy and overall fitness of an organism. Although the function of p53 as a tumour suppressor ensures that we can't live without it, an integrated view of p53 suggests that not all of its functions are conducive to a long and healthy life.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Vousden, Karen |
| Authors: | Lane, D., and Vousden, K. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Nature Reviews Molecular Cell Biology |
| ISSN: | 1471-0072 |
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