Lin Oo, S., Venkatesh, S., Karthikeyan, V. , Arava, C. M., Pathikonda, S., Yu, P. K. N., Lau, T. C. K., Chen, X. and Roy, V. A.L. (2021) Highly sensitive and cost-effective portable sensor for early gastric carcinoma diagnosis. Sensors, 21(8), 2639. (doi: 10.3390/s21082639)
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Publisher's URL: https://www.mdpi.com/1424-8220/21/8/2639
Abstract
Facile and efficient early detection of cancer is a major challenge in healthcare. Herein we developed a novel sensor made from a polycarbonate (PC) membrane with nanopores, followed by sequence-specific Oligo RNA modification for early gastric carcinoma diagnosis. In this design, the gastric cancer antigen CA72-4 is specifically conjugated to the Oligo RNA, thereby inhibiting the electrical current through the PC membrane in a concentration-dependent manner. The device can determine the concentration of cancer antigen CA72-4 in the range from 4 to 14 U/mL, possessing a sensitivity of 7.029 µAU−1mLcm−2 with a linear regression (R2) of 0.965 and a lower detection limit of 4 U/mL. This device has integrated advantages including high specificity and sensitivity and being simple, portable, and cost effective, which collectively enables a giant leap for cancer screening technologies towards clinical use. This is the first report to use RNA aptamers to detect CA72-4 for gastric carcinoma diagnosis
| Item Type: | Articles |
|---|---|
| Additional Information: | Funding: We acknowledge the grants from RGC of HKSAR project number T42-103/16N. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Vellaisamy, Professor Roy and Karthikeyan, Dr Vaithinathan |
| Authors: | Lin Oo, S., Venkatesh, S., Karthikeyan, V., Arava, C. M., Pathikonda, S., Yu, P. K. N., Lau, T. C. K., Chen, X., and Roy, V. A.L. |
| College/School: | College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering |
| Journal Name: | Sensors |
| Publisher: | MDPI |
| ISSN: | 1424-8220 |
| ISSN (Online): | 1424-8220 |
| Published Online: | 09 April 2021 |
| Copyright Holders: | Copyright © 2021 by the authors |
| First Published: | First published in Sensors 21(8):2639 |
| Publisher Policy: | Reproduced under a Creative Commons license |
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