Highly sensitive and cost-effective portable sensor for early gastric carcinoma diagnosis

Lin Oo, S., Venkatesh, S., Karthikeyan, V., Arava, C. M., Pathikonda, S., Yu, P. K. N., Lau, T. C. K., Chen, X. and Roy, V. A.L. (2021) Highly sensitive and cost-effective portable sensor for early gastric carcinoma diagnosis. Sensors, 21(8), 2639. (doi: 10.3390/s21082639)

[img] Text
238448.pdf - Published Version
Available under License Creative Commons Attribution.

6MB

Publisher's URL: https://www.mdpi.com/1424-8220/21/8/2639

Abstract

Facile and efficient early detection of cancer is a major challenge in healthcare. Herein we developed a novel sensor made from a polycarbonate (PC) membrane with nanopores, followed by sequence-specific Oligo RNA modification for early gastric carcinoma diagnosis. In this design, the gastric cancer antigen CA72-4 is specifically conjugated to the Oligo RNA, thereby inhibiting the electrical current through the PC membrane in a concentration-dependent manner. The device can determine the concentration of cancer antigen CA72-4 in the range from 4 to 14 U/mL, possessing a sensitivity of 7.029 µAU−1mLcm−2 with a linear regression (R2) of 0.965 and a lower detection limit of 4 U/mL. This device has integrated advantages including high specificity and sensitivity and being simple, portable, and cost effective, which collectively enables a giant leap for cancer screening technologies towards clinical use. This is the first report to use RNA aptamers to detect CA72-4 for gastric carcinoma diagnosis

Item Type:Articles
Additional Information:Funding: We acknowledge the grants from RGC of HKSAR project number T42-103/16N.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Vellaisamy, Professor Roy
Authors: Lin Oo, S., Venkatesh, S., Karthikeyan, V., Arava, C. M., Pathikonda, S., Yu, P. K. N., Lau, T. C. K., Chen, X., and Roy, V. A.L.
College/School:College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
Journal Name:Sensors
Publisher:MDPI
ISSN:1424-8220
ISSN (Online):1424-8220
Published Online:09 April 2021
Copyright Holders:Copyright © 2021 by the authors
First Published:First published in Sensors 21(8):2639
Publisher Policy:Reproduced under a Creative Commons license

University Staff: Request a correction | Enlighten Editors: Update this record