Sansom, O. , Berger, J., Bishop, S., Hendrich, B., Bird, A. and Clarke, A. (2003) Deficiency of Mbd2 suppresses intestinal tumorigenesis. Nature Genetics, 34(2), pp. 145-147. (doi: 10.1038/ng1155)
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Abstract
Gene silencing through de novo methylation of CpG island promoters contributes to cancer. We find that Mbd2, which recruits co-repressor complexes to methylated DNA, is essential for efficient tumorigenesis in the mouse intestine. As Mbd2-deficient mice are viable and fertile, their resistance to intestinal cancer may be of therapeutic relevance.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Sansom, Professor Owen |
| Authors: | Sansom, O., Berger, J., Bishop, S., Hendrich, B., Bird, A., and Clarke, A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Nature Genetics |
| ISSN: | 1061-4036 |
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