Deficiency of Mbd2 suppresses intestinal tumorigenesis

Sansom, O. , Berger, J., Bishop, S., Hendrich, B., Bird, A. and Clarke, A. (2003) Deficiency of Mbd2 suppresses intestinal tumorigenesis. Nature Genetics, 34(2), pp. 145-147. (doi:10.1038/ng1155)

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Abstract

Gene silencing through de novo methylation of CpG island promoters contributes to cancer. We find that Mbd2, which recruits co-repressor complexes to methylated DNA, is essential for efficient tumorigenesis in the mouse intestine. As Mbd2-deficient mice are viable and fertile, their resistance to intestinal cancer may be of therapeutic relevance.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sansom, Professor Owen
Authors: Sansom, O., Berger, J., Bishop, S., Hendrich, B., Bird, A., and Clarke, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Nature Genetics
ISSN:1061-4036

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