Disposable electrochemical sensor using graphene oxide – chitosan modified carbon-based electrodes for the detection of tyrosine

Dervin, S., Ganguly, P. and Dahiya, R. S. (2021) Disposable electrochemical sensor using graphene oxide – chitosan modified carbon-based electrodes for the detection of tyrosine. IEEE Sensors Journal, 21(23), pp. 26226-26233. (doi: 10.1109/JSEN.2021.3073287)

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Abstract

Despite the many recent advances in disposable and wearable sensing technologies for point of care testing (POCT), few affordable, flexible, and disposable sensors are available for the detection of tyrosine (Tyr), a valuable biomarker for metabolic and neurodegenerative diseases. In this regard, the disposable screen-printed electrodes on flexible substrates are attractive. However, current screen-printed approaches for the detection of Tyr use rigid ceramic substrates, expensive metal nanoparticle conductive inks and stiff metal or metal oxide-based sensitive materials, that are not suitable for single-use disposable or wearable POCT devices. To address these challenges, this work presents a flexible and disposable electrochemical sensor using graphene oxide – chitosan (GO-CS) modified carbon-based electrodes for the detection of Tyr. The affordable and easy to fabricate sensor consists of a three-carbon electrode system screen printed on a flexible, low-cost polyvinyl chloride (PVC) substrate. GO and CS were chosen as the sensitive nanocomposite due to their natural abundance and excellent electrochemical sensing properties. Quantitative determination of Tyr using DPV revealed a linear proportional response between 1 and 100 μM, with a correlation coefficient of 0.9993. The GO-CS-screen-printed carbon sensor (SPCS) also offers a linear range detection limit of 5.86 μM, and excellent sensitivity (0.0846 μA μM-1) and repeatability (RSD = 4.02%). The GO-CS-SPCS thereby provides a promising platform for the active sensing elements of single-use, disposable, and wearable POCT devices suitable for early diagnosis and monitoring of metabolic or neurodegenerative diseases or nutritional management.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Dervin, Miss Saoirse and Dahiya, Professor Ravinder and Ganguly, Ms Priyanka
Authors: Dervin, S., Ganguly, P., and Dahiya, R. S.
College/School:College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
Journal Name:IEEE Sensors Journal
Publisher:IEEE
ISSN:1530-437X
ISSN (Online):1558-1748
Published Online:14 April 2021
Copyright Holders:Copyright © 2021 IEEE
First Published:First published in IEEE Sensors Journal 21(23): 26226-26233
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
301728Engineering Fellowships for Growth: Printed Tactile SKINRavinder DahiyaEngineering and Physical Sciences Research Council (EPSRC)EP/R029644/1ENG - Electronics & Nanoscale Engineering
303114Innovative Network for Training in Water and Food Quality using Disposable Sensors,Ravinder DahiyaEuropean Commission (EC)813680ENG - Electronics & Nanoscale Engineering