Bowman, P. R.T., Smith, G. L. and Gould, G. W. (2021) Run for your life: can exercise be used to effectively target GLUT4 in diabetic cardiac disease? PeerJ, 9, e11485. (doi: 10.7717/peerj.11485) (PMID:34113491) (PMCID:PMC8162245)
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Abstract
The global incidence, associated mortality rates and economic burden of diabetes are now such that it is considered one of the most pressing worldwide public health challenges. Considerable research is now devoted to better understanding the mechanisms underlying the onset and progression of this disease, with an ultimate aim of improving the array of available preventive and therapeutic interventions. One area of particular unmet clinical need is the significantly elevated rate of cardiomyopathy in diabetic patients, which in part contributes to cardiovascular disease being the primary cause of premature death in this population. This review will first consider the role of metabolism and more specifically the insulin sensitive glucose transporter GLUT4 in diabetic cardiac disease, before addressing how we may use exercise to intervene in order to beneficially impact key functional clinical outcomes.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Smith, Professor Godfrey and Bowman, Mr Peter and Gould, Professor Gwyn |
| Authors: | Bowman, P. R.T., Smith, G. L., and Gould, G. W. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
| Journal Name: | PeerJ |
| Publisher: | PeerJ |
| ISSN: | 2167-8359 |
| ISSN (Online): | 2167-8359 |
| Copyright Holders: | Copyright © 2021 Bowman et al. |
| First Published: | First published in PeerJ 9: e11485 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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