Regulation and function of the p53 tumor suppressor protein

Ryan, K. , Phillips, A. and Vousden, K. (2001) Regulation and function of the p53 tumor suppressor protein. Current Opinion in Cell Biology, 13(3), pp. 332-337. (doi:10.1016/S0955-0674(00)00216-7)

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Abstract

Loss of the p53 tumor suppressor pathway contributes to the development of most human cancers. p53 is a nuclear protein that functions as a regulator of transcription. Significant advances have been made recently in our understanding of how p53 function is regulated and the mechanisms by which p53 mediates its effects.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ryan, Professor Kevin and Vousden, Karen
Authors: Ryan, K., Phillips, A., and Vousden, K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Current Opinion in Cell Biology
ISSN:0955-0674

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