Splicing DNA-damage responses to turnour cell death

Crighton, D. and Ryan, K.M. (2004) Splicing DNA-damage responses to turnour cell death. Biochimica et Biophysica Acta: Reviews on Cancer, 1705(1), pp. 3-15. (doi: 10.1016/j.bbcan.2004.09.001)

Abstract

The ability of a tumour cell to evade programmed cell death (apoptosis) is crucial in the development of cancer. The process of apoptosis is complex and involves the careful interplay of a host of signalling molecules. Cellular stresses, such as DNA-damage, can initiate apoptosis through multiple pathways, all of which eventually lead to eradication of damaged cells that may otherwise go on to form a tumour. Moreover, the relevance of this to combating cancer is very strong since several therapeutic agents used to treat malignant disease utilize the cells' apoptotic machinery. The purpose of this review is to provide an insight into what we know about how apoptosis is initiated by DNA-damaging agents, how pro- and anti-apoptotic signals converge in the execution of cell death, and how such mechanisms can be perturbed in cancer

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Crighton, Dr Diane and Ryan, Professor Kevin
• Authors: Crighton, D., and Ryan, K.M.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Biochimica et Biophysica Acta: Reviews on Cancer
• ISSN: 0304-419X