Updates on ion and water transport by the Malpighian tubule

Dow, J. A.T. , Krause, S. A. and Herzyk, P. (2021) Updates on ion and water transport by the Malpighian tubule. Current Opinion in Insect Science, 47, pp. 31-37. (doi: 10.1016/j.cois.2021.02.018) (PMID:33705976)

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Abstract

The Malpighian (renal) tubule is capable of transporting fluid at remarkable rates. This review will focus on recent insights into the mechanisms by which these high rates are achieved and controlled, with particular reference to the tubules of Drosophila melanogaster, in which the combination of physiology and genetics has led to particularly rapid progress. Like many vertebrate epithelia, the Drosophila tubule has specialized cell types, with active cation transport confined to a large, metabolically active principal cell; whereas the smaller intercalated stellate cell controls chloride and water shunts to achieve net fluid secretion. Recently, the genes underlying many of these processes have been identified, functionally validated and localized within the tubule. The imminent arrival of new types of post-genomic data (notably single cell sequencing) will herald an exciting era of new discovery.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Krause, Dr Sue and Dow, Professor Julian and Herzyk, Dr Pawel
Authors: Dow, J. A.T., Krause, S. A., and Herzyk, P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Current Opinion in Insect Science
Publisher:Elsevier
ISSN:2214-5745
ISSN (Online):2214-5753
Published Online:08 March 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Current Opinion in Insect Science 47: 31-37
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
173817Functional analysis of insect neuropeptide G protein-coupled receptorsShireen DaviesBiotechnology and Biological Sciences Research Council (BBSRC)BB/P008097/1MCSB - Integrative & Systems Biology
174100FlyMet.org - a tissue-based metabolomic online resource for the Drosophila and systems biology communitiesJulian DowBiotechnology and Biological Sciences Research Council (BBSRC)BB/P024297/1MCSB - Integrative & Systems Biology