Dow, J. A.T. , Krause, S. A. and Herzyk, P. (2021) Updates on ion and water transport by the Malpighian tubule. Current Opinion in Insect Science, 47, pp. 31-37. (doi: 10.1016/j.cois.2021.02.018) (PMID:33705976)
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Abstract
The Malpighian (renal) tubule is capable of transporting fluid at remarkable rates. This review will focus on recent insights into the mechanisms by which these high rates are achieved and controlled, with particular reference to the tubules of Drosophila melanogaster, in which the combination of physiology and genetics has led to particularly rapid progress. Like many vertebrate epithelia, the Drosophila tubule has specialized cell types, with active cation transport confined to a large, metabolically active principal cell; whereas the smaller intercalated stellate cell controls chloride and water shunts to achieve net fluid secretion. Recently, the genes underlying many of these processes have been identified, functionally validated and localized within the tubule. The imminent arrival of new types of post-genomic data (notably single cell sequencing) will herald an exciting era of new discovery.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Krause, Dr Sue and Dow, Professor Julian and Herzyk, Dr Pawel |
Authors: | Dow, J. A.T., Krause, S. A., and Herzyk, P. |
College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
Journal Name: | Current Opinion in Insect Science |
Publisher: | Elsevier |
ISSN: | 2214-5745 |
ISSN (Online): | 2214-5753 |
Published Online: | 08 March 2021 |
Copyright Holders: | Copyright © 2021 The Authors |
First Published: | First published in Current Opinion in Insect Science 47: 31-37 |
Publisher Policy: | Reproduced under a Creative Commons License |
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