Direct imaging of glymphatic flow using H217O MRI

Alshuhri, M. S. , Gallagher, L., Work, L. and Holmes, W. (2021) Direct imaging of glymphatic flow using H217O MRI. JCI Insight, 6(10), e141159. (doi: 10.1172/jci.insight.141159) (PMID:33857020)

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Abstract

The recently proposed glymphatic pathway for solute transport and waste clearance from the brain has been the focus of intense debate. By exploiting an isotopically enriched MRI tracer, H217O, we directly imaged glymphatic water transport in the rat brain in vivo for the first time. Our results reveal glymphatic transport that is dramatically faster and more extensive than previously thought and unlikely to be explained by diffusion alone. Moreover, we confirm the critical role of aquaporin-4 channels in glymphatic transport.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gallagher, Mrs Lindsay and Alshuhri, Mohammed Shenan S and Work, Dr Lorraine
Authors: Alshuhri, M. S., Gallagher, L., Work, L., and Holmes, W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:JCI Insight
Publisher:American Society for Clinical Investigation
ISSN:2379-3708
ISSN (Online):2379-3708
Published Online:15 April 2021
Copyright Holders:Copyright © 2021 Alshuhri et al.
First Published:First published in JCI Insight 6(10): e141159
Publisher Policy:Reproduced under a Creative Commons licence

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