Recruited macrophages that colonize the post-inflammatory peritoneal niche convert into functionally divergent resident cells

Louwe, P. A., Badiola Gomez, L., Webster, H., Perona-Wright, G. , Bain, C. C., Forbes, S. J. and Jenkins, S. J. (2021) Recruited macrophages that colonize the post-inflammatory peritoneal niche convert into functionally divergent resident cells. Nature Communications, 12, 1770. (doi: 10.1038/s41467-021-21778-0) (PMID:33741914) (PMCID:PMC7979918)

Abstract

Inflammation generally leads to recruitment of monocyte-derived macrophages. What regulates the fate of these cells and to what extent they can assume the identity and function of resident macrophages is unclear. Here, we show that macrophages elicited into the peritoneal cavity during mild inflammation persist long-term but are retained in an immature transitory state of differentiation due to the presence of enduring resident macrophages. By contrast, severe inflammation results in ablation of resident macrophages and a protracted phase wherein the cavity is incapable of sustaining a resident phenotype, yet ultimately elicited cells acquire a mature resident identity. These macrophages also have transcriptionally and functionally divergent features that result from inflammation-driven alterations to the peritoneal cavity micro-environment and, to a lesser extent, effects of origin and time-of-residency. Hence, rather than being predetermined, the fate of inflammation-elicited peritoneal macrophages seems to be regulated by the environment.

• Item Type: Articles
• Additional Information: This work was supported by the Wellcome Trust (108906/Z/15/Z) with additional support from the Medical Research Council UK (MR/L008076/1 to S.J.J).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Webster, Miss Holly and Perona-Wright, Dr Georgia
• Authors: Louwe, P. A., Badiola Gomez, L., Webster, H., Perona-Wright, G., Bain, C. C., Forbes, S. J., and Jenkins, S. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Research Centre: College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology
• Journal Name: Nature Communications
• Publisher: Nature Research
• ISSN: 2041-1723
• ISSN (Online): 2041-1723
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in Nature Communications 12: 1770
• Publisher Policy: Reproduced under a Creative Commons License