RAS and RHO GTPases in G1-phase cell-cycle regulation

Coleman, M., Marshall, C. and Olson, M. (2004) RAS and RHO GTPases in G1-phase cell-cycle regulation. Nature Reviews Molecular Cell Biology, 5(5), pp. 355-366. (doi: 10.1038/nrm1365)

Abstract

As RAS mutations are among the most frequent alterations in human cancers, RAS proteins and their signalling pathways have been studied intensively. Here, we outline the contributions of H-RAS, N-RAS and K-RAS to cell-cycle progression and cell growth. We also summarize recent results that indicate how other members of the RAS-GTPase subfamily - including E-RAS, RHEB, R-RAS, TC21 and RAL, as well as RHO GTPases - promote proliferation by regulating the transcription, translation and degradation of key cell-cycle components.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Olson, Professor Michael
• Authors: Coleman, M., Marshall, C., and Olson, M.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Nature Reviews Molecular Cell Biology
• ISSN: 1471-0072