Bottromycins - biosynthesis, synthesis and activity

Franz, L., Kazmaier, U., Truman, A. W. and Koehnke, J. (2021) Bottromycins - biosynthesis, synthesis and activity. Natural Product Reports, (doi: 10.1039/D0NP00097C) (PMID:33621290) (Early Online Publication)

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Abstract

Covering: 1950s up to the end of 2020Bottromycins are a class of macrocyclic peptide natural products that are produced by several Streptomyces species and possess promising antibacterial activity against clinically relevant multidrug-resistant pathogens. They belong to the ribosomally synthesised and post-translationally modified peptide (RiPP) superfamily of natural products. The structure contains a unique four-amino acid macrocycle formed via a rare amidine linkage, C-methylation and a d-amino acid. This review covers all aspects of bottromycin research with a focus on recent years (2009-2020), in which major advances in total synthesis and understanding of bottromycin biosynthesis were achieved.

Item Type:Articles
Status:Early Online Publication
Refereed:Yes
Glasgow Author(s) Enlighten ID:Koehnke, Dr Jesko
Authors: Franz, L., Kazmaier, U., Truman, A. W., and Koehnke, J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Natural Product Reports
Publisher:Royal Society of Chemistry
ISSN:0265-0568
ISSN (Online):1460-4752
Published Online:23 February 2021
Copyright Holders:Copyright © 2021 The Royal Society of Chemistry
First Published:First published in Natural Product Reports 2021
Publisher Policy:Reproduced under a Creative Commons License

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