Mitochondrial quality control: from molecule to organelle

Roca-Portoles, A. and Tait, S. W.G. (2021) Mitochondrial quality control: from molecule to organelle. Cellular and Molecular Life Sciences, 78(8), pp. 3853-3866. (doi: 10.1007/s00018-021-03775-0) (PMID:33782711) (PMCID:PMC8106605)

Abstract

Mitochondria are organelles central to myriad cellular processes. To maintain mitochondrial health, various processes co-operate at both the molecular and organelle level. At the molecular level, mitochondria can sense imbalances in their homeostasis and adapt to these by signaling to the nucleus. This mito-nuclear communication leads to the expression of nuclear stress response genes. Upon external stimuli, mitochondria can also alter their morphology accordingly, by inducing fission or fusion. In an extreme situation, mitochondria are degraded by mitophagy. Adequate function and regulation of these mitochondrial quality control pathways are crucial for cellular homeostasis. As we discuss, alterations in these processes have been linked to several pathologies including neurodegenerative diseases and cancer.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Roca, Alba and Tait, Professor Stephen
• Authors: Roca-Portoles, A., and Tait, S. W.G.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Cellular and Molecular Life Sciences
• Publisher: Springer
• ISSN: 1420-682X
• ISSN (Online): 1420-9071
• Published Online: 29 March 2021
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in Cellular and Molecular Life Sciences 78(8): 3853-3866
• Publisher Policy: Reproduced under a Creative Commons licence

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
172856		Apoptosis as an oncogenic process: understanding and exploiting its dark-side	Stephen Tait	Cancer Research UK (CRUK)	C40872/A21448	Institute of Cancer Sciences