Photoactivated release of membrane impermeant sulfonates inside cells

Caldwell, S. T. , O'Byrne, S., Wilson, C., Cvetko, F., Murphy, M. P., McCarron, J. G. and Hartley, R. C. (2021) Photoactivated release of membrane impermeant sulfonates inside cells. Chemical Communications, 57(32), pp. 3917-3920. (doi: 10.1039/D0CC07713E) (PMID:33871501) (PMCID:PMC7611313)

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Photouncaging delivers compounds with high spatial and temporal control to induce or inhibit biological processes but the released compounds may diffuse out. We here demonstrate that sulfonate anions can be photocaged so that a membrane impermeable compound can enter cells, be uncaged by photoirradiation and trapped within the cell.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Caldwell, Dr Stuart and O'Byrne, Mr Sean and Hartley, Professor Richard
Authors: Caldwell, S. T., O'Byrne, S., Wilson, C., Cvetko, F., Murphy, M. P., McCarron, J. G., and Hartley, R. C.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Chemical Communications
Publisher:Royal Society of Chemistry
ISSN (Online):1364-548X
Published Online:12 March 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Chemical Communications 57(32): 3917-3920
Publisher Policy:Reproduced under a Creative Commons licence

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