Thümmler, K. , Ramming, A., Schulze-Koops, H. and Skapenko, A. (2009) Zelluläre Therapie von Autoimmunerkrankungen = Cellular therapy in autoimmune disease. Zeitschrift fur Rheumatologie, 68(4), pp. 337-339. (doi: 10.1007/s00393-009-0458-y) (PMID:19337742)
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Abstract
In addition to natural thymus-derived regulatory T-cells (Tregs), peripherally-induced Tregs are of central importance in immune homeostasis. Homotypic interactions between activated effector T-cells and resting memory T-cells induced the generation of IL-10 and IFNgamma producing Tregs in vitro. This mechanism in Treg development allows new insights into T-cell vaccination, which has been employed in pilot trials of multiple sclerosis and rheumatoid arthritis with promising results.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Muecklisch, Dr Katja |
| Authors: | Thümmler, K., Ramming, A., Schulze-Koops, H., and Skapenko, A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Zeitschrift fur Rheumatologie |
| Publisher: | Springer |
| ISSN: | 0340-1855 |
| ISSN (Online): | 1435-1250 |
| Published Online: | 02 April 2009 |
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