Stem cell ageing: does it happen and can we intervene?

Bellantuono, I. and Keith, W.N. (2007) Stem cell ageing: does it happen and can we intervene? Expert Reviews in Molecular Medicine, 9(31), pp. 1-20. (doi:10.1017/S146239940700049X)

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Abstract

Adult stem cells have become the focus of intense research in recent years as a result of their role in the maintenance and repair of tissues. They exert this function through their extensive expansion (self-renewal) and multipotent differentiation capacity. Understanding whether adult stem cells retain this capacity throughout the lifespan of the individual, or undergo a process of ageing resulting in a decreased stem cell pool, is an important area of investigation. Progress in this area has been hampered by lack of suitable models and of appropriate markers and assays to identify stem cells. However, recent data suggest that an understanding of the mechanisms governing stem cell ageing can give insight into the mechanism of tissue ageing and, most importantly, advance our ability to use stem cells in cell and gene therapy strategies.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Keith, Professor Nicol
Authors: Bellantuono, I., and Keith, W.N.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Expert Reviews in Molecular Medicine
ISSN:1462-3994

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