Pemetrexed: a multitargeted antifolate (ALIMTA, LY-231514)

Jones, R. and Twelves, C. (2002) Pemetrexed: a multitargeted antifolate (ALIMTA, LY-231514). Expert Review of Anticancer Therapy, 2(1), pp. 13-22. (doi: 10.1586/14737140.2.1.13)

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Pemetrexed is a new member of the antifolate class of anticancer drugs. Here we describe how it is activated, its mode of action and its pharmacokinetics. Three single-agent Phase I trials are described with particular reference to the observed spectrum of toxicity but also anticancer activity. Several areas of antitumor activity have been explored further in Phase II trials and these are also reported here, as are early studies of pemetrexed in combination with other anticancer agents. Although the results of Phase III studies are not yet available, pemetrexed has promising activity in a number of solid tumors. We conclude by speculating about its future role in the care of patients.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Jones, Professor Robert
Authors: Jones, R., and Twelves, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Expert Review of Anticancer Therapy

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