Fatal peripheral neuropathy following FLA chemotherapy

Osborne, W., Holyoake, T., McQuaker, I. and Parker, A. (2004) Fatal peripheral neuropathy following FLA chemotherapy. Clinical and Laboratory Haematology, 26(4), pp. 295-296. (doi: 10.1111/j.1365-2257.2004.00613.x)

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Abstract

We discuss a case with significant progressive peripheral neurological deterioration following administration of both fludarabine and cytarabine as part of the FLA (fludarabine and cytarabine) regime. Of particular interest is that toxicity only occurred during the second course of FLA and sixth course of Ara-C containing chemotherapy. At this point, a new antifungal agent had been commenced, suggesting a possible drug interaction enhancing the risk of known neurological toxicity with this regime.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Parker, Dr Anne and Holyoake, Professor Tessa
Authors: Osborne, W., Holyoake, T., McQuaker, I., and Parker, A.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Clinical and Laboratory Haematology
ISSN:0141-9854

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