OPA1 and PARL keep a lid on apoptosis

Gottlieb, E. (2006) OPA1 and PARL keep a lid on apoptosis. Cell, 126(1), pp. 27-29. (doi: 10.1016/j.cell.2006.06.030)

Abstract

A change in the shape of mitochondrial cristae must take place to attain rapid and complete release of cytochrome c during apoptosis. In this issue of Cell, Cipolat et al. (2006) and Frezza et al. (2006) show that a rhomboid intramembrane protease PARL and a dynamin-related protein OPA1 are critical regulators of cristae remodeling.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Gottlieb, Professor Eyal
• Authors: Gottlieb, E.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Cell
• ISSN: 0092-8674