Hulswit, R. J.G., Paesen, G. C., Bowden, T. A. and Shi, X. (2021) Recent advances in bunyavirus glycoprotein research: precursor processing, receptor binding and structure. Viruses, 13(2), e353. (doi: 10.3390/v13020353) (PMID:33672327) (PMCID:PMC7926653)
Text
235093.pdf - Published Version Available under License Creative Commons Attribution. 4MB |
Abstract
The Bunyavirales order accommodates related viruses (bunyaviruses) with segmented, linear, single-stranded, negative- or ambi-sense RNA genomes. Their glycoproteins form capsomeric projections or spikes on the virion surface and play a crucial role in virus entry, assembly, morphogenesis. Bunyavirus glycoproteins are encoded by a single RNA segment as a polyprotein precursor that is co- and post-translationally cleaved by host cell enzymes to yield two mature glycoproteins, Gn and Gc (or GP1 and GP2 in arenaviruses). These glycoproteins undergo extensive N-linked glycosylation and despite their cleavage, remain associated to the virion to form an integral transmembrane glycoprotein complex. This review summarizes recent advances in our understanding of the molecular biology of bunyavirus glycoproteins, including their processing, structure, and known interactions with host factors that facilitate cell entry.
Item Type: | Articles |
---|---|
Keywords: | R.J.G.H. is supported by the European Molecular Biology Organisation (ALTF 869-2019). T.A.B., G.C.P., and R.J.G.H. are supported by the Medical Research Council (MR/S007555/1). X.S. is supported by the Wellcome Trust (Grant 099220/B/12/Z to RME). The Wellcome Centre for Human Genetics is supported by the Wellcome Trust grant 203141/Z/16/Z. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Shi, Dr Xiaohong |
Authors: | Hulswit, R. J.G., Paesen, G. C., Bowden, T. A., and Shi, X. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Viruses |
Publisher: | MDPI |
ISSN: | 1999-4915 |
ISSN (Online): | 1999-4915 |
Copyright Holders: | Copyright © 2021 The Authors |
First Published: | First published in Viruses 13(2):353 |
Publisher Policy: | Reproduced under a Creative Commons License |
University Staff: Request a correction | Enlighten Editors: Update this record