Recent advances in bunyavirus glycoprotein research: precursor processing, receptor binding and structure

Hulswit, R. J.G., Paesen, G. C., Bowden, T. A. and Shi, X. (2021) Recent advances in bunyavirus glycoprotein research: precursor processing, receptor binding and structure. Viruses, 13(2), e353. (doi: 10.3390/v13020353) (PMID:33672327) (PMCID:PMC7926653)

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Abstract

The Bunyavirales order accommodates related viruses (bunyaviruses) with segmented, linear, single-stranded, negative- or ambi-sense RNA genomes. Their glycoproteins form capsomeric projections or spikes on the virion surface and play a crucial role in virus entry, assembly, morphogenesis. Bunyavirus glycoproteins are encoded by a single RNA segment as a polyprotein precursor that is co- and post-translationally cleaved by host cell enzymes to yield two mature glycoproteins, Gn and Gc (or GP1 and GP2 in arenaviruses). These glycoproteins undergo extensive N-linked glycosylation and despite their cleavage, remain associated to the virion to form an integral transmembrane glycoprotein complex. This review summarizes recent advances in our understanding of the molecular biology of bunyavirus glycoproteins, including their processing, structure, and known interactions with host factors that facilitate cell entry.

Item Type:Articles
Keywords:R.J.G.H. is supported by the European Molecular Biology Organisation (ALTF 869-2019). T.A.B., G.C.P., and R.J.G.H. are supported by the Medical Research Council (MR/S007555/1). X.S. is supported by the Wellcome Trust (Grant 099220/B/12/Z to RME). The Wellcome Centre for Human Genetics is supported by the Wellcome Trust grant 203141/Z/16/Z.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Shi, Dr Xiaohong
Authors: Hulswit, R. J.G., Paesen, G. C., Bowden, T. A., and Shi, X.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Viruses
Publisher:MDPI
ISSN:1999-4915
ISSN (Online):1999-4915
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Viruses 13(2):353
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
168602Molecular analyses of arbovirus-host interactionsAgnes SimpsonWellcome Trust (WELLCOTR)099220/B/12/ZIII-MRC-GU Centre for Virus Research