Neutrophil dynamics in the tumor microenvironment

McFarlane, A. J., Fercoq, F., Coffelt, S. B. and Carlin, L. M. (2021) Neutrophil dynamics in the tumor microenvironment. Journal of Clinical Investigation, 131(6), e143759. (doi: 10.1172/JCI143759) (PMID:33720040)

Abstract

The tumor microenvironment profoundly influences the behavior of recruited leukocytes and tissue-resident immune cells. These immune cells, which inherently have environmentally driven plasticity necessary for their roles in tissue homeostasis, dynamically interact with tumor cells and the tumor stroma and play critical roles in determining the course of disease. Among these immune cells, neutrophils were once considered much more static within the tumor microenvironment; however, some of these earlier assumptions were the product of the notorious difficulty in manipulating neutrophils in vitro. Technological advances that allow us to study neutrophils in context are now revealing the true roles of neutrophils in the tumor microenvironment. Here we discuss recent data generated by some of these tools and how these data might be synthesized into more elegant ways of targeting these powerful and abundant effector immune cells in the clinic.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Coffelt, Professor Seth and Carlin, Dr Leo
• Authors: McFarlane, A. J., Fercoq, F., Coffelt, S. B., and Carlin, L. M.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Research Centre: College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology
• Journal Name: Journal of Clinical Investigation
• Publisher: American Society for Clinical Investigation
• ISSN: 0021-9738
• ISSN (Online): 1558-8238
• Copyright Holders: Copyright © 2021 American Society for Clinical Investigation
• First Published: First published in Journal of Clinical Investigation 131(6): e143759
• Publisher Policy: Reproduced in accordance with the publisher copyright policy

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
174115		CRUK Centre Renewal	Owen Sansom	Cancer Research UK (CRUK)	C7932/A25142	CS - Beatson Institute for Cancer Research