Neutrophil dynamics in the tumor microenvironment

McFarlane, A. J., Fercoq, F., Coffelt, S. B. and Carlin, L. M. (2021) Neutrophil dynamics in the tumor microenvironment. Journal of Clinical Investigation, 131(6), e143759. (doi: 10.1172/JCI143759) (PMID:33720040)

[img] Text
234946.pdf - Accepted Version

1MB

Abstract

The tumor microenvironment profoundly influences the behavior of recruited leukocytes and tissue-resident immune cells. These immune cells, which inherently have environmentally driven plasticity necessary for their roles in tissue homeostasis, dynamically interact with tumor cells and the tumor stroma and play critical roles in determining the course of disease. Among these immune cells, neutrophils were once considered much more static within the tumor microenvironment; however, some of these earlier assumptions were the product of the notorious difficulty in manipulating neutrophils in vitro. Technological advances that allow us to study neutrophils in context are now revealing the true roles of neutrophils in the tumor microenvironment. Here we discuss recent data generated by some of these tools and how these data might be synthesized into more elegant ways of targeting these powerful and abundant effector immune cells in the clinic.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Coffelt, Dr Seth and Carlin, Dr Leo
Authors: McFarlane, A. J., Fercoq, F., Coffelt, S. B., and Carlin, L. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Journal of Clinical Investigation
Publisher:American Society for Clinical Investigation
ISSN:0021-9738
ISSN (Online):1558-8238
Copyright Holders:Copyright © 2021 American Society for Clinical Investigation
First Published:First published in Journal of Clinical Investigation 131(6): e143759
Publisher Policy:Reproduced in accordance with the publisher copyright policy

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
174115CRUK Centre RenewalOwen SansomCancer Research UK (CRUK)C7932/A25142CS - Beatson Institute for Cancer Research