Programming gels over a wide pH range using multicomponent systems

Panja, S. , Dietrich, B. , Shebanova, O., Smith, A. J. and Adams, D. J. (2021) Programming gels over a wide pH range using multicomponent systems. Angewandte Chemie (International Edition), 60(18), pp. 9973-9977. (doi: 10.1002/anie.202101247) (PMID:33605524)

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Multicomponent hydrogels offer a tremendous opportunity to prepare useful and exciting materials that cannot be accessed using a single component. Here, we describe an unusual multi‐component low molecular weight gelling system that exhibits pH‐responsive behavior involving cooperative hydrogen bonding between the components, allowing it to maintain a gel phase across a wide pH range. Unlike traditional acid‐triggered gels, our system undergoes a change in the underlying molecular packing and maintains the β‐sheet structure both at acidic and basic pH. We further establish that autonomous programming between these two gel states is possible by an enzymatic reaction which allows us to prepare gels with improved mechanical properties.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Dietrich, Bart and Adams, Dave and Panja, Dr Santanu
Authors: Panja, S., Dietrich, B., Shebanova, O., Smith, A. J., and Adams, D. J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Angewandte Chemie (International Edition)
ISSN (Online):1521-3773
Published Online:19 February 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Angewandte Chemie (International Edition) 60(18):9973-9977
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
174004Multicomponent Supramolecular HydrogelsDave AdamsEngineering and Physical Sciences Research Council (EPSRC)EP/L021978/2Chemistry