Tetra-arylborate lipophilic anions as targeting groups

Gaddale Devanna, K. K. et al. (2021) Tetra-arylborate lipophilic anions as targeting groups. Chemical Communications, 57(25), pp. 3147-3150. (doi: 10.1039/D0CC07924C) (PMID:33634803) (PMCID:PMC8062962)

[img] Text
234370.pdf - Published Version
Available under License Creative Commons Attribution.



Tetraphenylborate (TPB) anions traverse membranes but are excluded from mitochondria by the membrane potential (Δψ). TPB-conjugates also distributed across membranes in response to Δψ, but surprisingly, they rapidly entered cells. They accumulated within lysosomes following endocystosis. This pH-independent targeting of lysosomes makes possible new classes of probe and bioactive molecules.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Caldwell, Dr Stuart and Gaddale Devanna, Dr Kishore Kumar and Hartley, Professor Richard
Authors: Gaddale Devanna, K. K., Gawel, J. M., Prime, T. A., Cvetko, F., Benincá, C., Caldwell, S. T., Negoda, A., Harrison, A., James, A. M., Pavlov, E. V., Murphy, M. P., and Hartley, R. C.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Chemical Communications
Publisher:Royal Society of Chemistry
ISSN (Online):1364-548X
Published Online:18 February 2021
Copyright Holders:Copyright © The Royal Society of Chemistry 2021
First Published:First published in Chemical Communications 57: 3147-3150
Publisher Policy:Reproduced under a Creative Commons licence

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
165401Developing chemical mass spectrometry probes to assess the production of reactive oxygen species in vivoRichard HartleyBiotechnology and Biological Sciences Research Council (BBSRC)BB/I012826/1Chemistry
172617Exploring mitochondrial metabolism in health and disease using targeted biological chemistryRichard HartleyWellcome Trust (WELLCOTR)110158/Z/15/ZChemistry