Stromal‐immune cell cross talk fundamentally alters the lung microenvironment following tissue insult

Worrell, J. C. and MacLeod, M. K.L. (2021) Stromal‐immune cell cross talk fundamentally alters the lung microenvironment following tissue insult. Immunology, 163(3), pp. 239-249. (doi: 10.1111/imm.13319) (PMID:33556186) (PMCID:PMC8014587)

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Communication between stromal and immune cells is essential to maintain tissue homeostasis, mount an effective immune response, and promote tissue repair. This ‘crosstalk’ occurs in both the steady state and following a variety of insults, for example, in response to local injury, at sites of infection, or cancer. What do we mean by crosstalk between cells? Reciprocal activation and/or regulation occurs between immune and stromal cells, by direct cell contact and indirect mechanisms, including the release of soluble cytokines. Moving beyond cell to cell contact, and this review investigates the complexity of ‘cross‐space’ cellular communication. We highlight different examples of cellular communication by a variety of lung stromal and immune cells following tissue insults. This review examines how the ‘geography of the lung microenvironment’ is altered in various disease states, more specifically we investigate how this influences lung epithelial cells and fibroblasts via their communication with immune cells and each other.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Worrell, Dr Julie and Macleod, Dr Megan
Authors: Worrell, J. C., and MacLeod, M. K.L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Immunology
ISSN (Online):1365-2567
Published Online:08 February 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Immunology 163(3): 239-249
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
302383Communication between lung immune and stromal cells drives tissue protective immune memoryMegan MacLeodWellcome Trust (WELLCOTR)210703/Z/18/ZIII - Immunology