Is mitochondrial reactive oxygen species production proportional to oxygen consumption? A theoretical consideration

Hou, C., Metcalfe, N. B. and Salin, K. (2021) Is mitochondrial reactive oxygen species production proportional to oxygen consumption? A theoretical consideration. BioEssays, 43(4), 2000165. (doi: 10.1002/bies.202000165) (PMID:33543487)

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Abstract

It has been assumed that at the whole organismal level, the mitochondrial reactive oxygen species (ROS) production is proportional to the oxygen consumption. Recently, a number of researchers have challenged this assumption, based on the observation that the ROS production per unit oxygen consumed in the resting state of mitochondrial respiration is much higher than that in the active state. Here, we develop a simple model to investigate the validity of the assumption and the challenge of it. The model highlights the significance of the time budget that mitochondria operate in the different respiration states. The model suggests that under three physiologically possible conditions, the difference in ROS production per unit oxygen consumed between the respiration states does not upset the proportionality between the whole animal ROS production and oxygen consumption. The model also shows that mitochondrial uncoupling generally enhances the proportionality.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Metcalfe, Professor Neil and Salin, Dr Karine
Authors: Hou, C., Metcalfe, N. B., and Salin, K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:BioEssays
Publisher:Wiley
ISSN:0265-9247
ISSN (Online):1521-1878
Published Online:04 February 2021
Copyright Holders:Copyright © 2021 Wiley Periodicals LLC
First Published:First published in BioEssays 43(4):2000165
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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