Peri‐ictal magnetic resonance imaging characteristics in dogs with suspected idiopathic epilepsy

Nagendran, A., McConnell, J. F., De Risio, L., José‐López, R. , Gutierrez Quintana, R. , Robinson, K., Platt, S. R., Masian, D. S., Maddox, T. and Gonçalves, R. (2021) Peri‐ictal magnetic resonance imaging characteristics in dogs with suspected idiopathic epilepsy. Journal of Veterinary Internal Medicine, 35(2), pp. 1008-1017. (doi: 10.1111/jvim.16058) (PMID:33559928) (PMCID:PMC7995424)

Abstract

Background: The pathophysiology of changes in magnetic resonance imaging (MRI) detected after a seizure is not fully understood. Objective: To characterize and describe seizure‐induced changes detected by MRI. Animals: Eighty‐one client‐owned dogs diagnosed with idiopathic epilepsy. Methods: Data collected retrospectively from medical records and included anatomical areas affected, T1‐, T2‐weighted and T2‐FLAIR (fluid‐attenuated inversion recovery) appearance, whether changes were unilateral or bilateral, symmetry, contrast enhancement, mass effect, and, gray and white matter distribution. Diffusion‐ and perfusion weighted maps were evaluated, if available. Results: Seizure‐induced changes were T2‐hyperintense with no suppression of signal on FLAIR. Lesions were T1‐isointense (55/81) or hypointense (26/81), local mass effect (23/81) and contrast enhancement (12/81). The majority of changes were bilateral (71/81) and symmetrical (69/71). The most common areas affected were the hippocampus (39/81) cingulate gyrus (33/81), hippocampus and piriform lobes (32/81). Distribution analysis suggested concurrence between cingulate gyrus and pulvinar thalamic nuclei, the cingulate gyrus and parahippocampal gyrus, hippocampus and piriform lobe, and, hippocampus and parahippocampal gyrus. Diffusion (DWI) characteristics were a mixed‐pattern of restricted, facilitated, and normal diffusion. Perfusion (PWI) showed either hypoperfusion (6/9) or hyperperfusion (3/9). Conclusions and Clinical Importance: More areas, than previously reported, have been identified that could incur seizure‐induced changes. Similar to human literature, DWI and PWI changes have been identified that could reflect the underlying metabolic and vascular changes.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Gutierrez Quintana, Mr Rodrigo and Jose-Lopez, Mr Roberto
• Authors: Nagendran, A., McConnell, J. F., De Risio, L., José‐López, R., Gutierrez Quintana, R., Robinson, K., Platt, S. R., Masian, D. S., Maddox, T., and Gonçalves, R.
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: Journal of Veterinary Internal Medicine
• Publisher: Wiley
• ISSN: 0891-6640
• ISSN (Online): 1939-1676
• Published Online: 09 February 2021
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in Journal of Veterinary Internal Medicine 35(2): 1008-1017
• Publisher Policy: Reproduced under a Creative Commons licence