Pulmonary adenocarcinoma in two alpacas (Vicugna pacos)

Moore, S. J., Wessels, M., McFadzean, H., Bell, F. and Treharne, Z. V. (2020) Pulmonary adenocarcinoma in two alpacas (Vicugna pacos). Veterinary Record Case Reports, 8(4), e001266. (doi: 10.1136/vetreccr-2020-001266)

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Abstract

We describe here two cases of pulmonary neoplasia in alpacas: case 1 was a 19‐year‐old female huacaya alpaca that was submitted to investigate sudden death with possible previous weight loss. Gross and histological examination revealed changes consistent with primary lepidic‐type pulmonary adenocarcinoma (previously bronchioalveolar carcinoma) with metastases to the thorax and abdomen. Case 2 was a six‐year‐old male castrated Suri alpaca with a 3‐week history of weight loss and inappetance that was euthanased following a short period of recumbency and respiratory signs. Gross and histological features in this case were consistent with a diagnosis of metastatic adenocarcinoma affecting the lungs and lymph nodes. Masses from both alpacas were further characterised using immunohistochemistry for thyroid transcription factor 1 (TTF‐1), pan cytokeratin AE1/AE3 and vimentin. We show that histological subtype and TTF‐1 and AE1/AE3 immunoreactivity can be used to differentiate primary and metastatic pulmonary adenocarcinomas in the lungs of alpacas.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Bell, Mr Frazer
Authors: Moore, S. J., Wessels, M., McFadzean, H., Bell, F., and Treharne, Z. V.
College/School:College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Veterinary Record Case Reports
Publisher:BMJ Publishing Group
ISSN:2052-6121
ISSN (Online):2052-6121
Published Online:21 December 2020
Copyright Holders:Copyright © 2020 British Veterinary Association
First Published:First published in Veterinary Record Case Reports 8(4):e001266
Publisher Policy:Reproduced under a Creative Commons licence

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