Brain imaging of executive function with the computerised multiple elements test

Fuentes-Claramonte, P. et al. (2021) Brain imaging of executive function with the computerised multiple elements test. Brain Imaging and Behavior, 15(5), pp. 2317-2329. (doi: 10.1007/s11682-020-00425-0) (PMID:33501628)

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Abstract

The Computerised Multiple Elements Test (CMET) is a novel executive task to assess goal management and maintenance suitable for use within the fMRI environment. Unlike classical executive paradigms, it resembles neuropsychological multi-elements tests that capture goal management in a more ecological way, by requiring the participant to switch between four simple games within a specified time period. The present study aims to evaluate an fMRI version of the CMET and examine its brain correlates. Thirty-one healthy participants performed the task during fMRI scanning. During each block, they were required to play four simple games, with the transition between games being made either voluntarily (executive condition) or automatically (control condition). The executive condition was associated with increased activity in fronto-parietal and cingulo-opercular regions, with anterior insula activity linked to better task performance. In an additional analysis, the activated regions showed to form functional networks during resting-state and to overlap the executive fronto-parietal and cingulo-opercular networks identified in resting-state with independently defined seeds. These results show the ability of the CMET to elicit activity in well-known executive networks, becoming a potential tool for the study of executive impairment in neurological and neuropsychiatric populations in a more ecological way than classical paradigms.

Item Type:Articles
Additional Information:This work was supported by the CIBERSAM and the Catalonian Government (2014-SGR-1573 and 2017-SGR-1271 to FIDMAG). Also by a grant from the Plan Nacional de I + D + i 2013– 2016: Juan de la Cierva-formación contract (FJCI-2015-25278 to PF-C). And by the Instituto de Salud Carlos III, co-funded by European Union (ERDF/ESF, “Investing in your future”): Miguel Servet Research contracts (CPII13/00018 to RS and MS10/00596 to EP-C), and Research Project Grants (PI14/01151 to RS, PI14/01148 to EP-C and PI14/01691 to PM).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Evans, Professor Jonathan and Cullen, Dr Breda
Authors: Fuentes-Claramonte, P., Santo-Angles, A., Argila-Plaza, I., Lechón, M., Guardiola-Ripoll, M., Almodovar-Payá, C., Cullen, B., Evans, J. J., Manly, T., Gee, A., Maristany, T., Sarró, S., Pomarol-Clotet, E., McKenna, P. J., and Salvador, R.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing
Journal Name:Brain Imaging and Behavior
Publisher:Springer
ISSN:1931-7557
ISSN (Online):1931-7565
Published Online:26 January 2021
Copyright Holders:Copyright © 2021 The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature
First Published:First published in Brain Imaging and Behavior 2021
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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