Dyeing fungi: amphotericin B based fluorescent probes for multiplexed imaging

Baibek, A., Üçüncü, M., Short, B., Ramage, G. , Lilienkampf, A. and Bradley, M. (2021) Dyeing fungi: amphotericin B based fluorescent probes for multiplexed imaging. Chemical Communications, 57(15), pp. 1899-1902. (doi: 10.1039/D0CC08177A) (PMID:33491716)

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The clinically used antifungal polyene amphotericin B was conjugated, via the mycosamine and the aglycon moieties, to fluorophores. The Cy5 conjugated probe showed selective labelling of fungi in the presence of bacteria, allowing multiplexed imaging and identification of microbial species in a co-culture of fungi and Gram-positive and Gram-negative bacteria.

Item Type:Articles
Additional Information:The authors would like to thank the Engineering and Physical Sciences Research Council (UKRI, EPSRC, UK) Interdisciplinary Research Collaboration grants EP/K03197X/1 and EP/R005257/1 for funding.
Glasgow Author(s) Enlighten ID:Ramage, Professor Gordon
Authors: Baibek, A., Üçüncü, M., Short, B., Ramage, G., Lilienkampf, A., and Bradley, M.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Chemical Communications
Publisher:Royal Society of Chemistry
ISSN (Online):1364-548X
Published Online:19 January 2021
Copyright Holders:Copyright © 2021 The Royal Society of Chemistry
First Published:First published in Chemical Communications 57(15): 1899-1902
Publisher Policy:Reproduced under a Creative Commons License

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