Effect-site controlled patient maintained propofol sedation: a volunteer safety study

Anderson, K.J., Leitch, J., Green, J.S. and Kenny, G.N. (2005) Effect-site controlled patient maintained propofol sedation: a volunteer safety study. Anaesthesia, 60(3), 235 -238. (doi:10.1111/j.1365-2044.2004.04071.x)

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Publisher's URL: http://dx.doi.org/10.1111/j.1365-2044.2004.04071.x

Abstract

Effect-site concentration is a mathematical term related to the clinical effect of a drug. We have designed a patient-maintained sedation system for delivering propofol to the predicted effect-site concentration rather than plasma concentration. To assess its efficacy and safety, 20 healthy volunteers deliberately attempted to over-sedate themselves using the system. The new effect-site concentration driven system delivered sedation successfully, and more rapidly than its predecessor. Fifteen volunteers ended the study when the system automatically reduced the effect-site concentration after 6 min of no button presses despite verbal contact and maintenance of arterial oxygen saturation (at effect-site concentration 1.8–3.8 μg.ml1). Four out of 20 volunteers ended with minor arterial desaturation (lowest 88% at effect-site concentration 2.6–3.4 μg.ml1). One volunteer ended after loss of verbal contact at effect-site concentration 3.4 μg.ml1. Further modification of the system's design is necessary before it can be recommended for routine practice.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:UNSPECIFIED
Authors: Anderson, K.J., Leitch, J., Green, J.S., and Kenny, G.N.
Subjects:R Medicine > RD Surgery
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Anaesthesia
ISSN:0003-2409

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