Boehm, M., Hjalmarson, A., Kjekshus, J., Laufs, U., McMurray, J., and van Veldhuisen, D.J. (2005) Heart failure and statins - Why do we need a clinical trial? Zeitschrift Fuer Kardiologie, 94 (4). pp. 223-230. ISSN 0300-5860 (doi:10.1007/s00392-005-0210-9)
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The effect of statins to reduce mortality and morbiditiy in primary and secondary prevention as well as in acute coronary syndroms is well established. Recent data show that pleiotropic effects might also have direct effects on the myocardial cell. However, in chronic heart failure the outcome is inversely related to LDL-plasma concentrations and other pleiotropic effects might impair mitochondrial function. Since there are no safety data on the use of statins in chronic heart failure, a controlled randomized and placebo-controlled trial is urgently needed.
|Glasgow Author(s):||McMurray, Prof John|
|Authors:||Boehm, M., Hjalmarson, A., Kjekshus, J., Laufs, U., McMurray, J., and van Veldhuisen, D.J.|
|College/School:||College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences|
College of Medical Veterinary and Life Sciences
|Journal Name:||Zeitschrift Fuer Kardiologie|