Comparative animal mucomics: inspiration for functional materials from ubiquitous and understudied biopolymers

Cerullo, A. R. et al. (2020) Comparative animal mucomics: inspiration for functional materials from ubiquitous and understudied biopolymers. ACS Biomaterials Science and Engineering, 6(10), pp. 5377-5398. (doi: 10.1021/acsbiomaterials.0c00713) (PMID:33320564)

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Abstract

The functions of secreted animal mucuses are remarkably diverse and include lubricants, wet adhesives, protective barriers, and mineralizing agents. Although present in all animals, many open questions related to the hierarchical architectures, material properties, and genetics of mucus remain. Here, we summarize what is known about secreted mucus structure, describe the work of research groups throughout the world who are investigating various animal mucuses, and relate how these studies are revealing new mucus properties and the relationships between mucus hierarchical structure and hydrogel function. Finally, we call for a more systematic approach to studying animal mucuses so that data sets can be compared, omics-style, to address unanswered questions in the emerging field of mucomics. One major result that we anticipate from these efforts is design rules for creating new materials that are inspired by the structures and functions of animal mucuses.

Item Type:Articles
Keywords:Bioinspired materials, biomimetics, functional materials, mucins, mucus, omics.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Barnes, Dr William
Authors: Cerullo, A. R., Lai, T. Y., Allam, B., Baer, A., Barnes, W. J. P., Barrientos, Z., Deheyn, D. D., Fudge, D. S., Gould, J., Harrington, M. J., Holford, M., Hung, C.-S., Jain, G., Mayer, G., Medina, M., Monge-Nájera, J., Napolitano, T., Espinosa, E. P., Schmidt, S., Thompson, E. M., and Braunschweig, A. B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:ACS Biomaterials Science and Engineering
Publisher:American Chemical Society
ISSN:2373-9878
ISSN (Online):2373-9878
Published Online:24 August 2020

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