Body fluid proteomics for biomarker discovery: lessons from the past hold the key to success in the future

Good, D., Thongboonkerd, V., Novak, J., Bascands, J., Schanstra, J., Coon, J., Dominiczak, A. and Mischak, H. (2007) Body fluid proteomics for biomarker discovery: lessons from the past hold the key to success in the future. Journal of Proteome Research, 6(12), pp. 4549-4555. (doi:10.1021/pr070529w)

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Abstract

This article provides a view on biomarker discovery using body fluid proteomics. Relevant issues are discussed, including the inherent differences between biological fluids and experimental design to maximize the efficiency of moving from the bench to bedside. The need for universalizing the meaning of the term “biomarker”, based on a set of universal characterization/validation requirements, is emphasized. Several recent examples of successful transitions from bench-top proteomics to clinical practice are given

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Dominiczak, Professor Anna
Authors: Good, D., Thongboonkerd, V., Novak, J., Bascands, J., Schanstra, J., Coon, J., Dominiczak, A., and Mischak, H.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Journal of Proteome Research
ISSN:1535-3893

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