Congenic/consomic models of hypertension

Graham, D., McBride, M., Brain, N. and Dominiczak, A. (2005) Congenic/consomic models of hypertension. In: Fennell, J.P. and Baker, A.H. (eds.) Hypertension. Series: Methods in Molecular Medicine (108). Humana Press, pp. 3-15. ISBN 978-1-58829-323-7 (doi: 10.1385/1-59259-850-1:003)

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Human essential hypertension is a complex, multifactorial, quantitative trait under polygenic control. Despite major recent advances in genome sequencing and statistical tools, the genetic dissection of essential hypertension still provides a formidable challenge. Genetic models of essential hypertension such as the spontaneously hypertensive stroke-prone rat (SHRSP) provide the scientist with genetic homogeneity, not possible within a human population, to aid the search for causative genes. The principal strategy in the rat has been the identification of quantitative trait loci (QTL) responsible for blood-pressure regulation by genome-wide scanning. In this chapter we focus on congenic and consomic breeding strategies for the confirmation of QTL and the genetic dissection of the implicated regions

Item Type:Book Sections
Glasgow Author(s) Enlighten ID:Dominiczak, Professor Anna
Authors: Graham, D., McBride, M., Brain, N., and Dominiczak, A.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Methods in Molecular Medicine
Publisher:Humana Press

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