Sodium–glucose co‐transporter 2 inhibitors in heart failure: beyond glycaemic control. A position paper of the Heart Failure Association of the European Society of Cardiology

Seferović, P. M. et al. (2020) Sodium–glucose co‐transporter 2 inhibitors in heart failure: beyond glycaemic control. A position paper of the Heart Failure Association of the European Society of Cardiology. European Journal of Heart Failure, 22(9), pp. 1495-1503. (doi: 10.1002/ejhf.1954) (PMID:32618086)

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Abstract

Heart failure (HF) is common and associated with a poor prognosis, despite advances in treatment. Over the last decade cardiovascular outcome trials with sodium–glucose co-transporter 2 (SGLT2) inhibitors in patients with type 2 diabetes mellitus have demonstrated beneficial effects for three SGLT2 inhibitors (empagliflozin, canagliflozin and dapagliflozin) in reducing hospitalisations for HF. More recently, dapagliflozin reduced the risk of worsening HF or death from cardiovascular causes in patients with chronic HF with reduced left ventricular ejection fraction, with or without type 2 diabetes mellitus. A number of additional trials in HF patients with reduced and/or preserved left ventricular ejection fraction are ongoing and/or about to be reported. The present position paper summarises recent clinical trial evidence and discusses the role of SGLT2 inhibitors in the treatment of HF, pending the results of ongoing trials in different populations of patients with HF.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Jhund, Dr Pardeep and Petrie, Professor Mark
Authors: Seferović, P. M., Fragasso, G., Petrie, M., Mullens, W., Ferrari, R., Thum, T., Bauersachs, J., Anker, S. D., Ray, R., Çavuşoğlu, Y., Polovina, M., Metra, M., Ambrosio, G., Prasad, K., Seferović, J., Jhund, P. S., Dattilo, G., Čelutkiene, J., Piepoli, M., Moura, B., Chioncel, O., Ben Gal, T., Heymans, S., Boer, R. A., Jaarsma, T., Hill, L., Lopatin, Y., Lyon, A. R., Ponikowski, P., Lainščak, M., Jankowska, E., Mueller, C., Cosentino, F., Lund, L., Filippatos, G. S., Ruschitzka, F., Coats, A. J.S., and Rosano, G. M.C.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:European Journal of Heart Failure
Publisher:Wiley
ISSN:1388-9842
ISSN (Online):1879-0844
Published Online:02 July 2020
Copyright Holders:Copyright © 2020 European Society of Cardiology
First Published:First published in European Journal of Heart Failure 22(9): 1495-1503
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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