Membrane voltage as a dynamic platform for spatio-temporal signalling, physiological and developmental regulation

Klejchova, M. , Silva-Alvim, F. A.L., Blatt, M. R. and Alvim, J. C. (2021) Membrane voltage as a dynamic platform for spatio-temporal signalling, physiological and developmental regulation. Plant Physiology, 185(4), pp. 1523-1541. (doi: 10.1093/plphys/kiab032) (PMID:33598675)

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Abstract

Membrane voltage arises from the transport of ions through ion-translocating ATPases, ion-coupled transport of solutes, and ion channels, and is an integral part of the bioenergetic ′currency′ of the membrane. The dynamics of membrane voltage - so-called action, systemic, and variation potentials - have also led to a recognition of their contributions to signal transduction, both within cells and across tissues. Here we review the origins of our understanding of membrane voltage and its place as a central element in regulating transport and signal transmission. We stress the importance of understanding voltage as a common intermediate that acts both as a driving force for transport - an electrical ′substrate′ - and as a product of charge flux across the membrane, thereby interconnecting all charge-carrying transport across the membrane. The voltage interconnection is vital to signalling via second messengers that rely on ion flux, including cytosolic free Ca2+, H+, and the synthesis of reactive oxygen species generated by integral membrane, respiratory burst oxidases. These characteristics inform on the ways in which long-distance voltage signals and voltage oscillations give rise to unique gene expression patterns and influence physiological, developmental, and adaptive responses such as systemic acquired resistance to pathogens and to insect herbivory.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Blatt, Professor Michael and Alvim, Mr Jonas and Alvim, Fernanda Aparecida and Klejchova, Mrs Martina
Authors: Klejchova, M., Silva-Alvim, F. A.L., Blatt, M. R., and Alvim, J. C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Plant Physiology
Publisher:Oxford University Press
ISSN:0032-0889
ISSN (Online):1532-2548
Published Online:03 February 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Plant Physiology 185(4): 1523-1541
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
173107SAURs in stomatal regulation New Title: 15 NSFBIO SAUR regulation of stomatal apertureMichael BlattBiotechnology and Biological Sciences Research Council (BBSRC)BB/P011586/1MCSB - Plant Sciences
172696Synthesis of Microcompartments in Plants for Enhanced Carbon FixationMichael BlattBiotechnology and Biological Sciences Research Council (BBSRC)BB/N01832X/1MCSB - Plant Sciences