Effect of rosuvastatin on outcomes in chronic haemodialysis patients - Design and rationale of the AURORA study.

Fellstrom, B. et al. (2005) Effect of rosuvastatin on outcomes in chronic haemodialysis patients - Design and rationale of the AURORA study. Current Controlled Trials in Cardiovascular Medicine, 6(9), (doi: 10.1159%2F000106803)

Abstract

Background Cardiovascular disease (CVD) is the leading cause of death in patients with end-stage renal disease (ESRD). Aims AURORA (A study to evaluate the Use of Rosuvastatin in subjects On Regular haemodialysis: an Assessment of survival and cardiovascular events) is the first large-scale international trial to assess the effects of statins on cardiovascular outcomes in patients with ESRD on chronic haemodialysis. Preliminary baseline data from the randomised population are presented. Methods A total of 2,775 patients from 280 centres in 25 countries were randomised into the study. Patients aged 50–80 years on regular chronic haemodialysis for at least 3 months before screening were eligible for inclusion. They were randomised 1:1 to receive either rosuvastatin 10 mg or placebo daily and assessed throughout the study. Results The mean age at baseline was 64 years. Most patients were male (62%) and 85% were white. The median time since commencing renal replacement was 32 months. Mean total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels were 4.53 mmol/l (175 mg/dl) and 2.57 mmol/l (99 mg/dl), respectively. Conclusion Results from the AURORA trial will impact on the current guidelines and use of statins in this patient population.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Cobbe, Professor Stuart and Jardine, Professor Alan
• Authors: Fellstrom, B., Zannad, F., Schmieder, R., Holdaas, H., Jardine, A., Rose, H., Wilpshaar, W., Bannister, K., Beutler, J., Chae, D., Cobbe, S.M., Vazquez, B.E., Gronhagen-Riska, C., Lima, J., Lins, R., McMahon, A., Mayer, G., Parving, H., Remuzzi, G., Samuelsson, O., Sonkodi, S., and Suleymanlar, G.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Current Controlled Trials in Cardiovascular Medicine