Genetic variation in the interleukin-10 gene promoter and risk of coronary and cerebrovascular events - The PROSPER study

Trompet, S. et al. (2007) Genetic variation in the interleukin-10 gene promoter and risk of coronary and cerebrovascular events - The PROSPER study. In: Rattan, S. and Akman, S. (eds.) Biogerontology: Mechanisms and Interventions. Series: Annals of the New York Academy of Sciences (1100). Blackwell Publishing: Oxford, pp. 189-198. ISBN 978-1-57331-679-8 (doi:10.1196/annals.1395.018)

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Abstract

Proinflammatory cytokines, like interleukin-6 (IL-6) and tumor necrosis factor-alpha JNF-u), are implicated in the development of atherosclerosis. The role of anti-inflammatory cytokines, like IL-10, is largely unknown. We investigated the association of four single nucleotide polymorphisms (SNPs) in the promoter region of the IL-10 gene (4259AG, - 1'682GA, -592CA, and -2849GA), with coronary and cerebrovascular disease in participants of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) trial. All associations were assessed with Cox proportional hazards models adjusted for sex, age, pravastatin use, and country. Haplotype analysis of the four SNPs showed a significant association between haplotype 4 (containing the -592A variant allele) and risk ofcoronary events (P = 0.019). Moreover, analysis of separate SNPs found a significant association between -2849AA carriers with incident stroke (HR (95%CI) 1.50 (1.04-2.17),P value = 0.02). Our study suggests that not only proinflammatory processes contribute to atherosclerosis, but that also anti-inflammatory cytokines may play an important role.

Item Type:Book Sections
Additional Information:5th European Congress of Biogerontology, Istanbul, TURKEY, SEP 16-20, 2006 Series ISSN: 0077-8923
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Macfarlane, Professor Peter and Norrie, Prof John and Stott J, Professor David and Ford, Professor Ian and Shepherd, Prof James and Gaw, Dr Allan and Packard, Professor Chris and Cobbe, Professor Stuart
Authors: Trompet, S., Pons, D., de Craen, A., Slagboom, P., Shepherd, J., Blauw, G., Murphy, M., Cobbe, S., Bollen, E., Buckley, B., Ford, I., Hyland, M., Gaw, A., Macfarlane, P., Packard, C., Norrie, J., Perry, I., Stott, D., Sweeney, B., Twomey, C., Westendorp, R., and Jukema, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
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Journal Name:Biogerontology: Mechanisms and Interventions
Publisher:Blackwell Publishing
ISSN:0077-8923
ISBN:978-1-57331-679-8

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