Tumor size is associated with the systemic inflammatory response but not survival in patients with primary operable colorectal cancer

Crozier, J.E., McMillan, D.C., McArdle, C.S., Angerson, W.J., Anderson, J.H., Horgan, P. and McKee, R.F. (2007) Tumor size is associated with the systemic inflammatory response but not survival in patients with primary operable colorectal cancer. Journal of Gastroenterology and Hepatology, 22(12), pp. 2288-2291. (doi: 10.1111/j.1440-1746.2006.04792.x)

Abstract

<p><b>AIM:</b> To examine the relationship between tumor diameter, C-reactive protein concentrations and survival in patients undergoing surgery for colorectal cancer.</p> <p><b>METHOD:</b> Tumor diameter and pathological characteristics of the resected specimen were assessed in 227 patients. Circulating concentrations of C-reactive protein were measured prior to surgery.</p> <p><b>RESULTS:</b> Ninety-six patients had an elevated C-reactive protein concentration (>10 mg/L) prior to surgery. Tumor size was associated with an elevated C-reactive protein concentration (P < 0.001). C-reactive protein concentrations (P < 0.001) were associated with poorer cancer-specific survival.</p> <p><b>CONCLUSION:</b> Prior to surgery, the maximal tumor diameter is associated with an elevated preoperative C-reactive protein concentration but not survival in patients with primary operable colorectal cancer.</p>

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Horgan, Professor Paul and Angerson, Dr Wilson and McKee, Dr Ruth and McMillan, Professor Donald
• Authors: Crozier, J.E., McMillan, D.C., McArdle, C.S., Angerson, W.J., Anderson, J.H., Horgan, P., and McKee, R.F.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
• Journal Name: Journal of Gastroenterology and Hepatology
• Publisher: Wiley-Blackwell Publishing
• ISSN: 0815-9319
• ISSN (Online): 1440-1746
• Published Online: 19 April 2007