Use of recombinant activated factor VII for bleeding in pancreatitis: a case series

Laffan, M. et al. (2005) Use of recombinant activated factor VII for bleeding in pancreatitis: a case series. Pancreas, 30(3), pp. 279-284. (doi: 10.1097/01.mpa.0000158026.30925.b4) (PMID:15782108)

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Objectives: To describe the effects of recombinant activated factor VII (rFVIIa) in the treatment of bleeding in a series of patients with acute or chronic pancreatitis. Methods: Twelve patients (age, 2.5-65 years) with pancreatitis and bleeding were treated with 18.5 to 120 μg/kg of rFVIIa. Eight patients also had sepsis/infection and/or disseminated intravascular coagulation (DIC). The effects of rFVIIa on bleeding, coagulation status, and transfusion requirements were noted. Results: Bleeding stopped in 4 patients, was markedly reduced in 4 patients, was reduced in 3 patients, and was remained unchanged in 1 patient. For most patients with pre- and post-rFVIIa data, coagulation parameters improved and transfusion requirements reduced. No thrombotic adverse events occurred. Seven patients died for reasons considered to be unrelated to rFVIIa treatment. Conclusions: This case series indicates that rFVIIa may be an effective hemostatic treatment of patients with pancreatitis suffering from massive bleeding. There were no thromboembolic events in any patient, including those with sepsis or DIC.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Tait, Dr Robert
Authors: Laffan, M., Tait, R. C., Blatný, J., Espersen, K., Grabowska, I., Loch-Bakoñska, L., Pauzkowska, A., Stasiak-Pikula, E., Michalska, G., Wendon, J., and Piotrowska, K.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Pancreas
Publisher:Lippincott, Williams & Wilkins
ISSN (Online):1536-4828

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